Society of Toxicology of Canada

Society for the Study of Reproduction


PhD, Reproductive Physiology, University of Guelph


Dr. Mike Wade, PhD

Research Scientist, Male Reproductive and Endocrine Toxicology

Environmental Health Centre, Ottawa, Ontario, Canada


Environmental influences on reproduction, development of the male reproductive tract, spermatogenesis, sperm maturation and function

Developmental effects of thyroid hormone toxicity

Testing Methodologies for detection of endocrine disrupting substances

  •  Molecular basis of toxicity to germ cells
  • The molecular basis of neurodevelopmental delays due to hypothyroidism (with Dr. Carole Yauk, EOT and Dr. Tom Zoeller, U of Mass Amherst)
  • Development and validation of rapid in vivo methods to identify thyroid disrupting substances.
  • In Vitro assays to study chemically induced fat cell differentiation.


Member of the  Advisory Group on Endocrine Disrupters Testing & Assessment, Test Guidelines Program of the Organization of Economic Cooperation & Development.

Leader, Reproductive & Developmental Toxicology Laboratory, Hazard Identification Division


Makaji E, Raha S, Wade MG, Holloway AC. 2011. Effect of environmental contaminants on beta cell function. Intern. J. Toxicol. (in press)

Dong, H, Paquette M, Williams A, Zoeller RT, Wade M, Yauk C.  2010  Thyroid Hormone May Regulate mRNA Abundance in Liver by acting on microRNAs.  PLos One PLos ONE, 5(8):e12136.

Langlois VS, Carew AC, Pauli BD, Wade MG, Cooke GM, et al. 2009 Low Levels of the Herbicide Atrazine Alters Sex Ratios and Reduces Metamorphic Success in Rana pipiens Tadpoles Raised in Outdoor Mesocosms. Environ Health Perspect 118(4):552-557

Dong H, Yauk CL, Rowan-Carroll A, You S-H, Zoeller RT, Lambert,I, Wade MG. 2009 Identification of Thyroid Hormone Receptor Binding Sites and Target Genes Using ChIP-on-Chip in Developing Mouse Cerebellum. PLoS ONE 4(2): e4610. doi:10.1371/journal.pone.0004610

M. Garner, M.C. Turner, P. Ghadirian, D. Krewski, M.G. Wade. 2008 Overview: Testicular Cancer and Hormonally Active Agents.  J. Toxicol. Environ. Health B 11:260-275

Wade MG, Lee A, Williams A, Yauk C. 2008  Methoxyacetic acid-induced death of spermatocytes is associated with histone hyperacetylation Biol Reprod 78: 822-831

G. Pelletier, S. Masson, Y.-L. Wang, M.G. Wade, S. Mohottalage, P.Kumarathasan, R.Vincent, R. Poon, I. Chu. Proteomic investigation of 1,6-Dimethoxyhexane testicular toxicity. Environmental Toxicology and Pharmacology 24:129-133

H. Dong, C. Yauk, A.Williams, A.Lee, G.R. Douglas, M. Wade. 2007 Hepatic gene expression changes in hypothyroid juvenile mice: Characterization of a novel negative thyroid responsive element.  Endocrinology 148:3932-3940.

Wade, M. G., Poon, R., Li, N., Lee, A., McMahon, A., and Chu, I. (2006). Testicular Toxicity of Candidate Fuel Additive 1,6-Dimethoxyhexane: Comparison with Several Similar  Aliphatic Ethers. Toxicol.Sci. 89: 304 - 313.

Foster W.G., E.V. Younglai, O. Boutross Tadross, C.L. Hughes, M.G. Wade. 2004 Mammary Gland Morphology in Sprague Dawley Rats Following Treatment with an Organochlorine Mixture in Utero and Neonatal Genistein.  Toxicol Sci. 77:91 100.